A Reddit poster recently mentioned that one of his coworkers invested $10,000 in Amazon.com, Inc. AMZN 0.41% back in 1999 and now plans on using his roughly $600,000 in profits to buy a retirement home.

The poster then asked the Reddit community what single investment they would choose if they had to place a $10,000 25-year bet. Here’s a sampling of some of the suggestions.

The top poster suggested the SPDR S&P 500 ETF Trust SPY 0.16%. While others suggested variations on the S&P 500 bet, such as the Vanguard Admiral VFIAX mutual fund, many agreed with the general idea of market-wide diversification.

The discussion then moved to single-stock picks, and posters had the following 25-year investment suggestions:

• Gilead Sciences, Inc. GILD 0.11%- “has some crazy good drugs in the pipeline that could basically cure several very nasty diseases.”
• Illumina, Inc. ILMN 1.8%- “they sell gene sequencing machines, similar to selling shovels during the gold rush.”
• Mercadolibre Inc MELI 0.26%- “basically the eBay/Paypal/Amazon from 15 years ago.”
• JD.Com Inc (ADR) JD 5.62%- “stealing market share from Alibaba every year and [trades] at a very low multiple of projected cash flow despite ultra fast growth rate.”
• Ford Motor Company F 1.52%- “dividends alone would be a decent margin.”
• iShares MSCI Emerging Markets Indx (ETF) EEM 0.91%- “book value as well as the price to earnings is…

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